5-Amino-1MQ 50mg

Description

• Chemical Name: 5-amino-1-methylquinolin-1-ium iodide (typically supplied as the iodide salt)

• Structure: A small-molecule methylated quinoline derivative comprising an amino group attached to position 5 of the quinoline core. (Note: While categorized under research compounds, 5-Amino-1MQ is a synthetic small-molecule organic compound rather than a structured amino acid peptide sequence.)

  • NNMT Enzyme Inhibition: Investigating the compound’s selective inhibition of Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that regulates cellular energy metabolism and histone methylation.

  • Adipocyte Metabolism & Lipogenesis: Evaluating the compound’s capacity to alter lipid accumulation in mature adipocytes and shift metabolic dynamics away from fat storage in diet-induced obesity models.

  • Skeletal Muscle Regeneration: Probing the pathways through which NNMT inhibition rejuvenates senescent muscle stem cells (satellite cells), supporting muscle fiber repair and physical function restoration.

  • Cellular NAD+ Salvage Pathways: Examining changes in intracellular Nicotinamide Adenine Dinucleotide (NAD+) pools resulting from decreased NNMT activity, and its subsequent impact on sirtuin activity and mitochondrial bioenergetics.

  • Epigenetic Modulations: Researching how the preservation of S-adenosylmethionine (SAM) levels—via NNMT blockade—affects global DNA/histone methylation profiles and gene silencing mechanisms.