Description
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), consisting of the 44-amino acid sequence of human GHRH with an added trans-3-hexenoic acid group. This modification enhances its stability and potency, making it more resistant to enzymatic cleavage compared to natural GHRH. It functions by binding to and activating GHRH receptors in the pituitary gland, thereby stimulating the pulsatile synthesis and release of endogenous growth hormone. While its most prominent researched application is the management of HIV-associated lipodystrophy, current studies extensively explore its impact on broader metabolic disorders, non-alcoholic fatty liver disease (NAFLD), and age-related cognitive decline.
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